QIF-T0161
criticalCortical spreading depression initiation (autonomous glutamate wave)
Tier 4 — Demonstrated (Case Study / Observational)
Legacy status: EMERGING
Technique Details
- Tactic
- QIF-P.DS
- Status
- EMERGING
- Bands
- I0, N1, N2, N3
✚ Therapeutic Application
Brief suprathreshold focal stimulation raises local [K+]ext past CSD ignition threshold (~12mM). CaV-dependent NMDA activation required for ignition. Once ignited: SELF-PROPAGATING K+/glutamate positive feedback wave at 2-5mm/min across cortex. Attacker delivers brief burst and withdraws; CSD continues autonomously 1-5min. Aftermath: 5-15min cortical silence (spreading depression). ECT reliably generates postictal CSD in mice AND humans (Rosenthal 2025, Nature Communications). Distinct from T0026/T0029: self-propagating after trigger withdrawal.
Clinical Analog
CSD as migraine intervention target; ECT therapeutic mechanism
Treats
- migraine
- ECT mechanism research
Neural Impact
4 of 7 neural bands affected
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Scoring
Validation Status
Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.