QIF-T0160
criticalFUS-BBB breach as excitotoxic glutamate priming vector
Tier 5 — Theoretical (Modeled / Simulated)
Legacy status: THEORETICAL
Technique Details
- Tactic
- QIF-P.DS
- Status
- THEORETICAL
- Bands
- I0, N1, N2, N3
✚ Therapeutic Application
High-intensity FUS + IV microbubbles -> acoustic cavitation -> BBB tight junction breach (24-48hr opening) -> perivascular ionic disequilibrium -> EAAT2 transport impaired -> extracellular glutamate elevated -> NMDA overactivation -> excitotoxic Ca2+ overload -> perilesional neuron death. EPISTEMIC FLAG: direct FUS-BBB->glutamate surge link is INFERRED from ischemia literature, not directly demonstrated in FUS-BBB studies. Attack surface: adversarial modification of therapeutic FUS parameters in clinical setting.
Clinical Analog
FUS-BBB opening for Alzheimer's drug delivery, glioblastoma
Treats
- Alzheimer's disease
- glioblastoma
Neural Impact
4 of 7 neural bands affected
Drag to rotate. Click a region to learn more.
Click or hover over a glowing region to see the attack techniques targeting it and their severity.
Scoring
Validation Status
Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.