QIF-T0159

high

LIFU astrocytic gliotransmission (acoustic TRPA1->extrasynaptic NMDA)

Tier 4 — Demonstrated (Case Study / Observational)

Legacy status: EMERGING

Technique Details

Tactic: QIF-N.MD
Status: EMERGING
Bands: I0, N1, N2

✚ Therapeutic Application

Pulsed LIFU (0.5MHz, <10% duty cycle) activates astrocytic TRPA1 mechanosensitive channels -> Ca2+ influx -> Best1-mediated glutamate release (gliotransmission) -> extrasynaptic NR2B-enriched NMDA receptors -> neuronal depolarization. Distinct: (1) acoustic not EM, (2) astrocyte-first not neuron-first, (3) gliotransmission not synaptic vesicle, (4) extrasynaptic NMDA pool pharmacologically distinct from synaptic. Confirmed: Gu & Han 2019, Current Biology.

Clinical Analog

tFUS for depression, OCD, essential tremor

Treats

depression
OCD
essential tremor

Neural Impact

3 of 7 neural bands affected

I0 N1 N2

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Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

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