QIF-T0155

high

Transcranial focused ultrasound DRN serotonin release (Piezo1/TRPA1 mechanotransduction)

Tier 4 — Demonstrated (Case Study / Observational)

Legacy status: EMERGING

Technique Details

Tactic: QIF-N.MD
Status: EMERGING
Bands: I0, N1, N2, N3

✚ Therapeutic Application

Low-intensity focused ultrasound (1.1MHz, 50% duty cycle, 30min/day x14 days) targets dorsal raphe nucleus with mm spatial precision. Acoustic pressure activates Piezo1 mechanosensitive channels (PNAS 2023) -> Ca2+ influx -> 5-HT release. LC-MS confirmed serotonin increase in DRN (Zeng 2022, PMID:35998565). No RF signature, no surface contact. High severity: precise deep targeting without EM emission.

Clinical Analog

tFUS for treatment-resistant depression via DRN

Treats

treatment-resistant depression
OCD

Neural Impact

4 of 7 neural bands affected

I0 N1 N2 N3

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Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

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