QIF-T0154

medium

VNS disynaptic serotonin upregulation (NTS->LC->DRN pathway)

Tier 2 — Validated (Independently Replicated)

Legacy status: CONFIRMED

Technique Details

Tactic: QIF-N.MD
Status: CONFIRMED
Bands: N1, N2, N3, N4

✚ Therapeutic Application

VNS activates vagal afferents -> NTS -> locus coeruleus (NE, obligate intermediary) -> dorsal raphe nucleus (DRN, 5-HT). LC lesioning completely blocks 5-HT response (Dorr & Debonnel 2006). 14-day latency for serotonin effect (acute NE only). Disynaptic peripheral-to-brainstem cascade distinct from T0009 (EM cortical) and T0136 (photon CCO).

Clinical Analog

VNS for treatment-resistant depression

Treats

treatment-resistant depression

Neural Impact

4 of 7 neural bands affected

N1 N2 N3 N4

Drag to rotate. Click a region to learn more.

Click or hover over a glowing region to see the attack techniques targeting it and their severity.

Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

Qinnovate Neural Security Atlas Edit this on GitHub