QIF-T0151

medium

TMS cholinergic cortical perturbation via mAChR (40-63ms TEP)

Tier 4 — Demonstrated (Case Study / Observational)

Legacy status: EMERGING

Technique Details

Tactic: QIF-E.RD
Status: EMERGING
Bands: I0, N1

✚ Therapeutic Application

Single-pulse TMS over SMA elicits TMS-evoked potentials (TEPs) suppressed by endogenous mAChR cholinergic tone. Scopolamine increases TEP at 40-63ms and enhances alpha synchronization. Distinct from SICI (GABA-A, ISI 1-5ms). Attack: TMS perturbation reveals/perturbs cholinergic status in BCI user.

Clinical Analog

TMS-EEG biomarker for Alzheimer's cholinergic deficit

Treats

Alzheimer's disease
cholinergic monitoring

Neural Impact

2 of 7 neural bands affected

I0 N1

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Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

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