QIF-T0146

medium

Gamma-tACS PV-interneuron GABA-A modulation (40Hz contact entrainment)

Tier 3 — Demonstrated (Lab-proven)

Legacy status: DEMONSTRATED

Technique Details

Tactic: QIF-E.RD
Status: DEMONSTRATED
Bands: I0, N1

✚ Therapeutic Application

40Hz tACS via contact electrodes drives PV+ fast-spiking GABAergic interneurons phase-locked at gamma. Sustained >10min: duration-dependent GABA-A decrease (SICI-measured, Nowak 2017). Distinct from T0010 (non-contact ELF) and GENUS (sensory, no electrodes).

Clinical Analog

Gamma-tACS for Parkinson's motor restoration

Treats

Parkinson's disease
motor learning

Neural Impact

2 of 7 neural bands affected

I0 N1

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Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

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