QIF-T0144

high

cTBS GABAergic LTD interneuron upregulation (theta-burst GABA increase)

Tier 2 — Validated (Independently Replicated)

Legacy status: CONFIRMED

Technique Details

Tactic: QIF-N.MD
Status: CONFIRMED
Bands: I0, N1

✚ Therapeutic Application

Continuous theta-burst stimulation (50Hz triplets at 5Hz, 40s, 600 pulses, ~80% AMT) induces LTD-like cortical suppression lasting 30-60min with MRS-confirmed GABA increase in M1. Distinct from SICI/LICI (paired-pulse) and T0010 (ELF entrainment). The GABA increase is a neuroplasticity response, not acute receptor activation.

Clinical Analog

cTBS for depression, chronic pain, post-stroke

Treats

treatment-resistant depression
chronic pain
stroke rehabilitation

Neural Impact

2 of 7 neural bands affected

I0 N1

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Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

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