QIF-T0143

medium

LICI-TMS GABA-B long-interval cortical inhibition (suprathreshold paired-pulse)

Tier 2 — Validated (Independently Replicated)

Legacy status: CONFIRMED

Technique Details

Tactic: QIF-N.MD
Status: CONFIRMED
Bands: I0, N1

✚ Therapeutic Application

Paired-pulse TMS: suprathreshold conditioning at ISI 50-200ms (peak 80-135ms) activates GABA-B metabotropic receptors. Gi-coupled GIRK K+ channel hyperpolarization. Pharmacologically distinct from SICI: baclofen enhances LICI, benzodiazepines do not. Maps directly to GABA-B IPSP kinetics.

Clinical Analog

LICI biomarker for epilepsy, TBI

Treats

epilepsy biomarker
traumatic brain injury

Neural Impact

2 of 7 neural bands affected

I0 N1

Drag to rotate. Click a region to learn more.

Click or hover over a glowing region to see the attack techniques targeting it and their severity.

Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

Qinnovate Neural Security Atlas Edit this on GitHub