QIF-T0142

medium

SICI-TMS GABA-A cortical inhibition (short-interval paired-pulse)

Tier 2 — Validated (Independently Replicated)

Legacy status: CONFIRMED

Technique Details

Tactic: QIF-N.MD
Status: CONFIRMED
Bands: I0, N1

✚ Therapeutic Application

Paired-pulse TMS: subthreshold conditioning stimulus (70-80% RMT) at ISI 1-5ms activates synaptic GABA-A inhibitory interneurons. Benzodiazepine-sensitive (gamma2 subunit). Distinct from T0009 (RF) and T0010 (ELF) by magnetic induction via contact coil + paired-pulse paradigm targeting GABA-A specifically.

Clinical Analog

Diagnostic SICI for ALS, stroke biomarker

Treats

ALS diagnosis
stroke motor mapping

Neural Impact

2 of 7 neural bands affected

I0 N1

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Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

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