QIF-T0139

medium

Photothermal gold nanoparticle TRPV1 dopamine activation

Tier 3 — Demonstrated (Lab-proven)

Legacy status: DEMONSTRATED

Technique Details

Tactic: QIF-N.NM
Status: DEMONSTRATED
Bands: I0, N1, N2

✚ Therapeutic Application

NIR light (680-1100nm, tunable by nanorod aspect ratio) absorbed by antibody-conjugated gold nanorods at neuronal membrane. Photothermal conversion raises local temperature above 43.8C TRPV1 activation threshold. Ca2+ influx triggers action potential. DA-specific effect inferred but not directly demonstrated in VTA. Narrow thermal safety window (43.8-47C).

Clinical Analog

Wireless photothermal deep brain stimulation

Treats

Parkinson's disease

Neural Impact

3 of 7 neural bands affected

I0 N1 N2

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Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

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