QIF-T0138

high

HUP photovoltaic nanoparticle dopamine stimulation (980nm)

Tier 4 — Demonstrated (Case Study / Observational)

Legacy status: EMERGING

Technique Details

Tactic: QIF-N.NM
Status: EMERGING
Bands: I0, N1, N2, N3

✚ Therapeutic Application

980nm NIR excitation of hybrid upconversion-photovoltaic (HUP) nanoparticles (NaYF4:Yb/Tm + WO3-x nanorods) injected into VTA. UCNPs upconvert to 450nm; WO3-x generates capacitive photocurrent that depolarizes neurons directly. NO genetic modification required. Triggers acute dopamine release. 78% Y-maze place preference in mice.

Clinical Analog

Non-genetic deep brain photovoltaic stimulation

Treats

Parkinson's disease
depression

Neural Impact

4 of 7 neural bands affected

I0 N1 N2 N3

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Scoring

NISS v1.1

0.0None

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

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