Skip to content

QIF-T0128

medium

Hedonic tone suppression

Tier 5 — Theoretical (Modeled / Simulated)

Legacy status: THEORETICAL

Technique Details

Tactic
QIF-N.MD
Status
THEORETICAL
Bands
N5, N6

Therapeutic Application

Suppression of ventral striatum and orbitofrontal cortex reward-related activity to reduce hedonic tone, causing loss of pleasure in normally enjoyable activities

Clinical Analog

DBS of subcallosal cingulate / ventral capsule for depression

Treats

  • treatment-resistant depression
  • anhedonia
  • bipolar depression (research)

Neural Impact

2 of 7 neural bands affected

N5 N6

Drag to rotate. Click a region to learn more.

Click or hover over a glowing region to see the attack techniques targeting it and their severity.

DSM-5-TR Diagnostic Mappings

Diagnostic category references for threat modeling, not diagnostic claims.

F32.2 Major Depressive Episode, Severe (anhedonia) F34.1 Persistent Depressive Disorder (Dysthymia) F48.1 Depersonalization-Derealization Disorder

Pathway: N3 (ventral striatum) → N4 (OFC) → N5 (reward network) — hedonic suppression

Following Poldrack (2006), brain region disruption does not uniquely predict psychiatric outcomes.

Scoring

NISS v1.1 NISS:1.1/BI:L/CR:N/CD:H/CV:E/RV:P/NP:P
5.4Medium
BICRCDCVRVNP
 

Governance

Neurorights at Risk

This technique threatens 3 of the 4 proposed neurorights (Ienca & Andorno, 2017).

Consent Complexity
0.96 / 4.0

FDORA §3305 Compliance

Non-Cyber Device (missing: software, network)
Regulatory Coverage
0.1 / 1.0
524B Requirements
TM VA SA PM
Regulatory Gaps
  • ! CVSS cannot express neural-specific impacts
  • ! Threat not yet in regulatory threat catalogs

Population Vulnerability

CRB vulnerability adjustment (γ=0.30) accounts for age, diagnosis severity, consent capacity, and device dependency.

Population NISS Base Adjusted Severity Delta
Adult (Default) 5.4 5.4 Medium -
Child (10yr) + ADHD 5.4 6.4 Medium +0.95
Adult with ALS 5.4 6.3 Medium +0.87

Validation Status

Theoretical / Not yet validated. This technique has not been independently tested. See the validation dashboard for what has been tested.

Qinnovate Neural Security Atlas Edit this on GitHub